This is a fantastic TEDx talk by Larry Smith. In a very compelling way, he shoots down all the excuses people make not to go after what they are truly passionate about in life.
The worst thing (though he doesn’t talk about this) is when people claim that these excuses have biblical authority. I see people do it all the time — and then judge people who disagree, claiming that they are somehow “less spiritual.” It is a truly, truly horrible thing because it is using the Bible as justification for low expectations and false thinking.
Go after what you are truly passionate about. Just do it for the glory of God and according to his standards. And quit thinking that there has to be an unavoidable dichotomy between accomplishment and relationships. Embrace the genius of the and.